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In a examine in breast most cancers cells, The mixture of lapatinib, a dual HER2/neu and EGFR tyrosine kinase inhibitor, with INK128 prevented equally HER2 and HER3 phosphorylation induced by INK128 and produced synergistic induction of mobile death in numerous HER2-favourable cell strains resistant to trastuzumab and lapatinib. In vivoThe marketed